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KMID : 1189420070200010115
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2007 Volume.20 No. 1 p.115 ~ p.129
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Study on the Anti-oxidative, Anti-microbial and Anti-cancer effect of Bibangtalmyungsan
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Han Hong-Jun
Choi Jung-Hwa
Park Su-Yeon
Kim Jong-Han
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Abstract
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Objectives: This study was carried out to evaluate anti-oxidative, anti-microbial and anti-cancer effect for clinical application of Bibangtalmyungsan (BTS)
Results: 1. The oxidative effects were measured by polyphenol, DPPH radical scavenging activity. BTS water extract was showed more effective than ethanol extract and also various solvent fractions from BTS water extract showed effective in the following order : ethyl acetate fraction > butanol fraction > hexane fraction chloroform fraction aqueous fraction 2. The results of anti-microbial effects were as follows. 1) Antibacterial activities of BTS extracts against Gram’s negative and positive bacteria were ineffective 2) Antifungal activities of the BTS extracts against Aspergillus spp. , Trichohyton mentagrophyte KTCC 1077 were not effective. 3. The result of anti-cancer effects were as followings: 1) BTS ethanol extract was more effective than water extract against Caco-2, Calu-6, but it had cytotoxic effect against NIH3T3. 2) On the Caco-2, effective only in ethyl acetate fraction. 3) On the Calu-6, the most effective in ethyl acetate fraction and effective In butanol fraction and hexane fraction 4) On the SUN-601, IC?? value was within 80 ug/ml in ethyl acetate fraction and hexane fraction. 5) On the HCT-1l6, the most effective in ethyl acetate fraction and effective in hexane fraction. 6) On the AML-2/WT, the most effective in ethyl acetate fractionand effective In hexane fraction. 7) On the NIH3T3, effective only in ethyl acetate 203.42 , but it was more ineffective than other cancer cells.
Conclusion: These result suggest that BTS has antioxidative, antifungal activities and cytotoxic effects against Caco-2, Calu-6, SUN-601, HCT-116, AML-2/WT and NIH3T3, especially ethyl acetate fraction from water extract has more effective in antioxidative and anticancer effects.
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KEYWORD
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Bibangtalmyungsan, anti-oxidative, anti-microbial, anti-cancer
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